News & Stories
2021
News
Humanizing Yeast ORC Sheds Light on Cancer Therapy and Human Development
Researchers from the Hong Kong University of Science and Technology (HKSUST) and the University of Hong Kong (HKU) recently demonstrated that the selectivity determinant of Origin Recognition Complex (ORC) for DNA binding lies in a 19-amino acid insertion helix in the Orc4 subunit, which is present in yeast but absent in human. Removal of this motif from Orc4 transforms the yeast ORC, which selects origins based on base-specific binding at defined locations, into one whose selectivity is dictated by chromatin landscape (genomic nucleosome profile), a characteristic feature shared by human ORC.
Further understanding of the preferred DNA shapes and nucleosome positioning requirements will provide new insights for the plasticity of the human ORC in selecting replication initiation sites during programmed development and disease transformation, and also help identify potential targets for anti-cancer drug screening and therapy design.
News
HKUST Collaborates with Hang Lung to Foster Young Mathematics Talent
The Hong Kong University of Science and Technology (HKUST) and Hang Lung Properties will co-organize the Hang Lung Mathematics Awards (HLMA) to empower Hong Kong secondary school students to realize their creative potential in mathematics and sciences, ignite their passion for intellectual discovery in the interests of society and humankind, and advance the development of STEM education.Founded in 2004, HLMA is an acclaimed mathematics research competition in Hong Kong. This biennial event has attracted over 2,200 participants from around 200 secondary schools and received almost 400 research papers, many demonstrating university-level academic standards. A total of HK$8 million in prize money has been awarded to past HLMA winners. The Chinese University of Hong Kong (CUHK) was the inaugural partner of the Award.
News
HKUST Researchers Discover a Novel Mechanism of Recruiting Arf Family Proteins to Specific Subcellular Localizations
Researchers of the Hong Kong University of Science and Technology (HKUST) recently uncovered a novel molecular mechanism that regulates the subcellular localizations of Arf proteins, shedding light on the mechanism underlying various inherited diseases and offering new insight to the treatment of them.