News & Stories
2020

News
New Method Identifies Adaptive Mutations in Complex Evolving Populations
A research team co-led by a scientist at the Hong Kong University of Science and Technology (HKUST) has developed a method to study how HIV mutates to escape the immune system in multiple patients, which could inform HIV vaccine design.
HIV, which can lead to AIDS, evolves rapidly and attacks the body’s immune system. Genetic mutations in the virus enable it to evade immune responses mounted by T cells and antibodies, which makes it all the more difficult to design an effective solution. While there is no effective cure for the virus currently available, it can be controlled with medication.
Now, the international research team has devised a new method from conventional statistical physics to reveal patterns of selection in HIV evolution using 14 patient data sets, providing a means to efficiently distinguishing the mutations that help the virus escape the immune system from those that are only random variations.