News & Stories

Boundless: What recent discovery has the HKUST research team made regarding the human enzyme DICER?Prof. Nguyen: Our discovery is genuinely groundbreaking. We found that the enzyme DICER, which is crucial for gene silencing, possesses a "dual-pocket" mechanism for measuring RNA. This is significant because it changes our understanding of how DICER interacts with RNA strands.Boundless: What exactly is “gene silencing”?Prof. Nguyen: Good question. Gene silencing means reducing or eliminating the expression of a specific gene. This process may occur naturally in cells or be induced artificially. Gene silencing is used to prevent the production of proteins from a targeted gene. This technique helps researchers study the function of a gene, investigate disease mechanisms, and develop gene-based therapies.

A research team led by Prof. SUN Jianwei, Chair Professor of the Department of Chemistry and Director of the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction at The Hong Kong University of Science and Technology (HKUST), has achieved a groundbreaking advance in organic synthesis and medicinal chemistry. The team has developed an air-stable chiral phosphine-catalyzed enantioselective approach to synthesize enantioenriched S(IV)-stereogenic vinyl sulfinamides—an under-explored class of organosulfur compounds with promising antiviral activity.

A research team from The Hong Kong University of Science and Technology (HKUST) has made a breakthrough discovery in understanding the molecular machinery of RNA silencing. The team uncovered how the human enzyme DICER achieves highly precise processing of microRNAs (miRNAs), advancing gene regulation research and offering new insights into the mechanisms underlying cancer, immune disorders, and genetic diseases. 

A research team from The Hong Kong University of Science and Technology (HKUST) has developed GrainBot, an AI-enabled toolkit that automatically extracts and quantifies multiple microstructural features from microscopy images. Designed to meet the growing need for data-driven and autonomous research workflows in materials science, the tool provides a systematic method for converting complex image information into quantitative data, thereby accelerating the discovery and development of next-generation materials.

A research team led by Prof. Kenward VONG, Assistant Professor from the Department of Chemistry at The Hong Kong University of Science and Technology (HKUST) has recently achieved a significant breakthrough by bioengineering a new type of glycan-targeting system known as “lectin-directed protein aggregation therapy (LPAT)”. Using this technology, they developed a therapy capable of preventing the onset and growth of metastatic breast cancers in mouse models.

A research team at The Hong Kong University of Science and Technology (HKUST) has developed an innovative urban food waste management framework by analyzing food waste data from 29 large cities worldwide, including Hong Kong, Beijing, and New York. The study shows that in cities with higher food waste moisture loads, such as Hong Kong, grinding food waste and diverting it into the sewage system is more effective than relying solely on landfilling. This approach can reduce overall greenhouse gas emissions by about 47% and lower total waste-management costs by about 11%. The research provides a new, quantitative basis for shaping food waste management strategies in cities around the globe.

The Hong Kong University of Science and Technology (HKUST) research team has developed a groundbreaking wastewater treatment technology that integrates a mesh bioreactor with an ultrasound-induced transient cavitation cleaning mechanism. The system can complete mesh cleaning within 3.8 seconds under anaerobic conditions and achieves 10-20 times higher flux than conventional membrane bioreactors (MBRs). The technology operates efficiently with substantially lower energy consumption, produces treated effluent surpassing international and local discharge standards, and reduces the cost of treating each cubic metre of wastewater to 50% of conventional MBRs, offering a sustainable solution for both municipal and industrial wastewater treatment.

The International Research Enrichment (IRE) Program at The Hong Kong University of Science and Technology (HKUST) School of Science is designed for students who feel a deep calling toward scientific discovery.Established in 2014, the IRE program offers a structured pathway for science students to engage deeply with research from an early stage, with many securing a research supervisor by their second year. The hallmark of IRE is its strong emphasis on global exposure. IRE students benefit from a scholarship that supports their required overseas internship (SCIE 3900 International Research Experience), often combined with an exchange semester. This financial assistance, coupled with flexibility in curriculum planning, enables IRE students to immerse themselves in extended international research opportunities.